Innovation of benzimidazole metal chelates as pharmaceutical agents

Metals and Ligands in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications. Medicinal Applications of Coordination Chemistry begins with a brief historical review and an introduction to the chemistry of d- and f- block metals. Subsequent sections discuss metallodrugs for several different applications, the design of new drugs and the relationship between structure and function. Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. The use of metals and their salts for medicinal purposes has been present throughout history. The interactions of transition metal complexes with DNA have been a subject of passionate research in the field of bioinorganic chemistry, ever since the discovery of cis-platin as an anticancer agent. It has been demonstrated that free radicals can damage DNA of bio-tissues, leading to increased rates of cancer.