Role of Osteoactivin in Bone Formation and Fracture Repair

Treatment of patients with osteoporosis is a major health care challenge and many pharmaceutical companies are focused on identifying novel therapeutic agents that can stimulate new bone formation. The proposed studies generate new information regarding the effects of Osteoactivin on bone growth in vivo, and its mechanisms of action in regulating bone cell differentiation and function. This information will help in developing new therapeutic strategies to selectively enhance bone formation in patients with significant bone loss.