Synthesis of Ibuprofen Derivatives and Their Biological Application

In the present research, therapeutically important five Ibuprofen derivatives were prepared in two steps. These two steps consist of formation of acid chloride and conversion of 2-(4-Isobutyl phenyl) – Propionyl chloride into active Ibuprofen amides. Amide derivatives of Ibuprofen were synthesized by well known Schotten-Baumann reaction for amide synthesis. In first step acid chloride was formed by the reaction of Ibuprofen with Thionyl Chloride (SOCl2). In second step the acid chloride was treated with different amines to give amide derivative 5% NaOH and DMF were also used in second step. A hot plate with magnetic stirrer was used during reflux for boiling and stirring the mixture. The derivative of Ibuprofen were separated and confirmed by melting point and FT-IR spectral data. The data obtained was confirmed the formation of respective products. Ibuprofen and its derivatives have great pharmacological importance. Derivatives have better analgesic and anti-inflammatory properties than parent drug (Ibuprofen).