Nonogaki disease

Gastric adenocarcinoma is the most important type of stomach cancers, and it is generally sporadic. However, about 10% of gastric adenocarcinoma occurs in familial pattern. The most important genetic causative factor in gastric adenocarcinoma is CDH1 germ line mutations, which cause the diffuse stomach cancer syndrome. Chen was probably the first to suggest the existence of neuroendocrine carcinoma of the stomach as a separate entity in 1988. This book describes the first Iraqi patient with familial mixed gastric neuroendocrine-adenocarcinoma. Ikue Nonogaki and his research group were probably the first to report the occurrence of non-syndromic familial adenocarcinoma-neuroendocrine gastric cancer. Therefore, the author would like to name this condition “Nonogaki Disease”. This book reported the occurrence of the first case of this disease in Iraq, which may be the fourth reported case in the world.