Single Nucleotide Polymorphisms among Established Ovarian Cancer Genes

Ovarian cancer has claimed the lives of hundreds of thousands of women globally. Although mortality rates decline with early diagnosis, this form of cancer is considered a silent killer due to its minor symptomatic presentation. This work focuses on the identification of genetic markers that may be utilized for the early detection of ovarian cancer. More specifically, single nucleotide polymorphisms (SNPs) occurring within transcription factor binding sites (TFBSs) were investigated, as these are considered to potentially influence the expression profiles of genes that may render susceptibility to ovarian cancer.