Biochemical Characterization of Matrix Gla Protein

Biochemical Characterization of Matrix Gla Protein

A study of the physical and calcification inhibitory properties of matrix Gla protein.

LAP Lambert Academic Publishing ( 2010-09-14 )

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The purpose of this dissertation was: 1) to biochemically characterize how purified matrix Gla protein (MGP) functions as a calcification inhibitor using two novel in vitro calcification assays; 2) to characterize MGP''s binding to apatite mineral; and 3) to characterize MGP purified from bone, cartilage, and serum using mass spectrometry. The data presented in this dissertation provide for the first time evidence of how purified MGP acts as an inhibitor of calcification and establishes that MGP accomplishes this function through direct interaction with calcium phosphate mineral.

Book Details:

ISBN-13:

978-3-8383-2477-7

ISBN-10:

3838324773

EAN:

9783838324777

Book language:

English

By (author) :

Francisco Villa

Number of pages:

156

Published on:

2010-09-14

Category:

Biology