Tumor suppressor gene activity in lung, colon and breast carcinomas

Tumor suppressor gene activity in lung, colon and breast carcinomas

PPP2R1B mechanisms of tumorigenesis and heritable cancer susceptibility

LAP Lambert Academic Publishing ( 2010-09-14 )

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The most common cancers of adults include lung, colon and breast carcinoma. The PP2A-Aβ gene (PPP2R1B) encodes a component of protein phosphatase 2A. The important role of protein phosphatase 2A in down regulating cell growth and the mutations of PP2A-Aβ in many human cancers suggest PP2A-Aβ is a tumor suppressor gene. Screening of cancer patient DNAs revealed alterations of PP2A-Aβ in various cancers and a germline alteration associated with breast carcinoma. Biochemical studies showed mutations in PP2A-Aβ reducing its ability to bind the PP2A complex. Transfecting the PP2A-Aβ gene into cancer cell lines conferred a relative growth disadvantage to transfected cells. Cell lines expressing exogenous PP2A-Aβ are found to have lower levels of β-catenin, suggesting the PP2A-Aβ gene is involved in regulating the Wnt signaling pathway. These studies elucidate the tumor suppressor qualities of the PP2A-Aβ gene, its role in heritable cancer susceptibility, the potential it has as a target for gene directed therapy of cancer, and should be useful to professionals studying the mechanisms and treatment of cancer.

Book Details:

ISBN-13:

978-3-8383-2500-2

ISBN-10:

3838325001

EAN:

9783838325002

Book language:

English

By (author) :

EDWARD ESPLIN

Number of pages:

80

Published on:

2010-09-14

Category:

Genetics