Osteoarthritis of the Human Knee

Osteoarthritis of the Human Knee

Composition and Mechanical Properties of osteoarthritic subchondral trabecular tibial bone

LAP Lambert Academic Publishing ( 10.12.2010 )

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Osteoarthritis is a disease that has been characterised historically by the focal destruction of cartilaginous tissue and hence, is defined as such. However, recent investigations have brought this pathology into contention with significant evidence implicating subchondral bone in the disease's pathophysiology. Early-stage primary osteoarthritic bone samples were harvested from both presenting medial and and non-presenting lateral compartments of diseased human tibia and were used to investigate the role of subchondral bone in the pathogenesis of primary human osteoarthritis. Significant differences in intrinsic tissue stiffness and mineralisation were observed in all samples presenting with clinically-defined, early-stage OA. Interstingly, non-presenting lateral samples also exhibited significant differences in stiffness and mineralisation. Hence, the presence of an early, non-presenting stage of OA initiation was observed in the bone tissue of these samples prior to overlying cartilaginous tissue damage. In conclusion, the classic 'wear' and 'tear' definition of this disease is no longer applicable to human knee OA.

Детали книги:

ISBN-13:

978-3-8433-8250-2

ISBN-10:

3843382506

EAN:

9783843382502

Язык книги:

English

By (author) :

John Gleeson

Количество страниц:

264

Опубликовано:

10.12.2010

Категория:

Механика, акустика