SYNTHETIC AND KINETIC STUDIES OF ISOCOUMARINS AND THEIR DERIVATIVES

SYNTHETIC AND KINETIC STUDIES OF ISOCOUMARINS AND THEIR DERIVATIVES

SYNTHETIC AND KINETIC STUDIES OF NATURALLY AND NON-NATURALLY OCCURRING ISOCOUMARINS AND SOME OF THEIR DIHYDRO DERIVATIVES

LAP Lambert Academic Publishing ( 01.08.2010 )

€ 79,00

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The work presented in this book consists of synthesis of naturally and non-naturally occurring isocoumarins and kinetic studies for the hydrolysis of isocoumarin and ketoesters. The isocoumarin, 3-n-propyl-6,7-(methylenedioxy)-1H-2-benzopyran-1- one, Xyridin A, was isolated in 1995. It has been used as folklore medicine in many countries. Its total synthesis has been carried out successfully. Another natural product, 6, 8-dihydroxy-3-[(2''-ethyl-(4''''-methoxyphenyl)]-3,4- dihydro- isocoumarin, (dl)-Agrimonolide, was isolated in 1958. Partial synthesis of this isocoumarin has been carried out successfully which may be a convenient route for its total synthesis. Non-naturally occurring isocoumarins and their dihydro derivatives have been synthesized as well. They include a series of methoxyphenylisocoumarins and dihydroisocoumarins and halogenated isocoumarins and dihydroisocoumarins. In the kinetic studies, the hydrolysis of 3-(2''''-chloro-6''''-flurobenzyl)isocoumarin and methyl-2[2''-oxo-3''-(2"-chloro-6"-flouro- phenyl)propyl]benzoate with KOH solution were monitored to probe the mechanism of the reaction. Role of solvent in the reactions have also been investigated.

Kitap detayları:

ISBN-13:

978-3-8383-8256-2

ISBN-10:

3838382560

EAN:

9783838382562

Kitabın dili:

English

Yazar:

Hafiz Badaruddin Ahmad

Sayfa sayısı:

228

Yayın tarihi:

01.08.2010

Kategori:

Organik kimya