Linkage analysis of MYP12 and MYP14 in families

Myopia is one of the leading causes of vision loss around the world. The combination of genetic and environmental influences on the development of myopia suggests that myopia is a complex disorder. Pedigree analysis, variable phenotypic expression level and the refractive error range in myopic individual suggest that it does not strictly follow the mendallion inheritance pattern. Unlinked pedigree suggests study at broader scale so that any other identified locus or any new locus may be discovered in myopic population of Pakistan.