Studies on Formulation and Development of Transdermal Patches

Transdermal patch of Curcumin was prepared for sustained the release, increase bioavailability of drug and patient compliance. The formulations were evaluated for parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release. Contour plot and 3D surface plot was drawn for each dependent variable. Check point batches were prepared to validate the evolved model. In vitro release data were fitted to various models to ascertain kinetic of drug release. The selected formulation was subjected to in-vitro skin permeation and Stability study.