LAP Lambert Academic Publishing ( 07.10.2014 )
€ 35,90
Michael J. LaMastra wrote this book based on his research while attending Roswell Park Cancer Institute for his first masters degree. While we knew that HPV-associated head and neck cancer was different from tobacco/alcohol related head and neck cancer, we did not know why. The answer was genomic instability. Human Papillomavirus type 16 (HPV-16) has been shown to be an independent etiologic agent, with virus-positive tumors exhibiting better prognoses.This study aimed to determine if there are quantitative and/or qualitative differences in the genomic instability patterns of HPV-16 positive and HPV-16 negative head and neck cancer. Mutational analyses of a small number of genes suggest that HPV-16 positive tumors may have different genomic alterations than HPV-16 negative tumors.For this study, DNA from head and neck cancers were collected at RPCI and subjected to PCR using oligonucleotides specific for the HPV-16 E6 gene. These samples underwent further analysis by array CGH which was performed in collaboration with the Microarray Facility at RPCI.
Детали книги: |
|
ISBN-13: |
978-3-659-50941-4 |
ISBN-10: |
3659509418 |
EAN: |
9783659509414 |
Язык книги: |
English |
By (author) : |
Michael J. LaMastra |
Количество страниц: |
52 |
Опубликовано: |
07.10.2014 |
Категория: |
Медицина |