β-Catenin, TCF, and ICAT

β-Catenin, TCF, and ICAT

Novel Roles in T Cell Development, Function, and Aging

LAP Lambert Academic Publishing ( 21.12.2009 )

€ 68,00

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In addition to working together to drive expression of target genes, β-catenin and TCF often work independently of each other. They both regulate several stages of T cell development, but their mode of action remains poorly understood. To study the specific role of β-catenin-TCF interactions in T cells, we generated transgenic mice that express ICAT, a naturally occurring inhibitor of β-catenin-TCF interactions, in the T cell lineage. We found that β-catenin-TCF interactions are important for thymocyte survival, but not for proliferation or differentiation. Interestingly, thymocyte aging slows down in ICAT-Tg mice, suggesting a role for β-catenin-TCF interactions in normal thymic involution. We also discovered that β-catenin-TCF interactions provide survival signals to activated T cells and promote differentiation of activated CD4 T cells into the default Th2 lineage. However, TCF represses Th1 differentiation independently of its interaction with β-catenin. This study, thus, provides novel insights into the role of β-catenin and TCF in T cell development, function, and aging, and should of interest to immunologists, developmental biologists, and gerontologists alike.

Kitap detayları:

ISBN-13:

978-3-8383-3450-9

ISBN-10:

3838334507

EAN:

9783838334509

Kitabın dili:

English

Yazar:

Mohammad Zulfiquer Hossain

Sayfa sayısı:

196

Yayın tarihi:

21.12.2009

Kategori:

Genetik