Synthesis and Drug Design of New Heterocycles of Biological Concern

In recent years, heterocyclic compounds are one of the most exploring fields in heterocyclic chemistry due to their diverse biological importance. Among the heterocyclic compounds, nitrogen, sulphur, oxygen heterocycles play a vital role in our day to day life. Inspired by the extensive advances of molecular hybridization with their significance, indoloisoquinoline, pyrimidine, thiazole-2-amine compounds are associated legitimately or by implication to N-bridged heterocyclic thiazolidinone, azetidinone, pi-conjugated 1,3,4-oxadiazole and heteroaromatic indole analogs. In line with previous reports new compounds have the biological potential as antimicrobial, anticancer, anti-TB, antioxidant activities. Molecular docking further supports the theoretical data with clear display of binding of molecules with protein and its effect.