REGENERATIVE ENDODONTICS

The genetic programming of the dental pulp cells leads them to develop into dentin- or dentin-like matrix-forming cells. Certain epigenetic signals—which have been studied in a variety of ex vivo and in vivo models—are necessary for differentiation. While tissue engineering and regenerative medicine inspired research and applications in areas like bone, cartilage and skin, it challenges the building of completely artificial organs, e.g., liver. The urgency of clinical emergencies drove the approaches toward all living tissues in the body, including dental structures. the design of biomimetic scaffolds aimed at achieving an efficient regenerative process. In addition, novel tissue engineering methodologies such as bio-printing have been used to better control the delivery of growth factors and cells in a three-dimensional environment.