Formulation and Evaluation of Mucoadhesive Microspheres of Rizatriptan

The present investigation involves formulation and evaluation of microspheres with Rizatriptan Benzoate as model drug for prolongation of drug release time. An attempt was made to prepare microspheres of Rizatriptan Benzoate by ionotropic gelation technique, with a view to deliver the drug at sustained / controlled manner in gastrointestinal tract and consequently into systemic circulation.Mucoadhesive technologies have often proven popular among the oral controlled drug delivery technologies because of their simplicity, easeof manufacturing, and high level of reproducibility and easy for scale up and process validation. Rizatriptan Benzoatedrug used for the treatment of migraine, was chosen as a model drug with an aim to develop a controlled release microsphere formulation. The microspheres were formulated by calcium chloride cross-linking method using various concentrations of HydroxyPropyl Methyl Cellulose and Chitosan by dropping the Drug-Polymer solution along with sodium alginate in calcium chloride solution.The prepared microspheres were evaluated for flow behavior, compatibility study, drug entrapment efficiency, In-vitro dissolution and mucoadhesive properties.