LAP Lambert Academic Publishing ( 04.07.2017 )
€ 35,90
The present work was investigated to evaluate the diuretic and antiurolithiatic activities on leaf extract of Saccharum officinarum. The leaf extract was administered to experimental rats orally at a dose of 200mg/ kg and 400mg/kg. Furosemide (5mg/kg) was used as standard for diuretic activity. The parameters measured for diuretic activity was total urine volume; urine electrolyte concentrations such as sodium, potassium, chloride and bicarbonates. In in-vitro antiurolithiatic activity, Calcium oxalate crystallization was induced by the addition of 0.01M sodium oxalate solutions in synthetic urine. The effect of extract (100, 200 and 500μg/ml) was studied by time course measurement of absorbance at 620 nm for ten minutes by means of a spectrophotometer. The extract showed inhibition at 120 sec (40.31, 60.46 and 63.56 %), and maximum inhibition of the crystallization of calcium oxalate at 600 seconds (55.24, 69.93 and 72.72%). In in-vivo antiurolithiatic activity, urolithiasis was induced in male rats by administering ethylene glycol (0.75% v/v) in drinking water for 28days and the parameters such as oxalate, calcium and phosphate were estimated.
Kitap detayları: |
|
ISBN-13: |
978-3-330-34467-9 |
ISBN-10: |
3330344679 |
EAN: |
9783330344679 |
Kitabın dili: |
English |
Yazar: |
Palaksha Mekerahally Narayanappa |
Sayfa sayısı: |
52 |
Yayın tarihi: |
04.07.2017 |
Kategori: |
Eczacılık |