LAP Lambert Academic Publishing ( 10.11.2014 )
€ 61,90
A series of newer 3-(4'-methoxyphenyl)-5-substituted phenylisoxazoles derivatives have been synthesized by reacting hydroxylamine hydrochloride with chalcone. The chalcones were formed by reacting different aromatic aldehydes with 4-methoxyacetophenone in presence of aqueos KOH. The acute toxicity study was carried on all the synthesized compounds and they were screened for their anti-inflammatory activity by carrageenan induced paw edema method. Anti-inflammatory studies showed statistically significant activity when compared to control indomethacin. The two most potent compounds giving good anti-inflammatory activity were further evaluated for their anti-ulcer activity. The compounds were subjected to docking and quantitative structure activity relationships (QSAR) studies.
Детали книги: |
|
ISBN-13: |
978-3-659-63299-0 |
ISBN-10: |
3659632996 |
EAN: |
9783659632990 |
Язык книги: |
English |
By (author) : |
Sahaya Asirvatham |
Количество страниц: |
144 |
Опубликовано: |
10.11.2014 |
Категория: |
Химическая технология |