LAP Lambert Academic Publishing ( 2018-07-19 )
€ 54,90
Galectins are a family of beta-galactoside-binding proteins located in a wide range of organisms, where they exert functions that can be mediated by carbohydrate-protein and protein-protein interactions. Using a protein engineering approach, galectin-3 constructs were produced and set to perform structural studies, which allowed to ascertain the position of key amino acids in the N-terminal playing fundamental roles in galectin-3 function, like apoptosis and metastasis. On the other hand, a comprehensive genetic mapping of the galectin family identified one particular Galectin-Related Protein located in bone marrow that has a high degree of sequence identity with galectins, sharing their jelly-roll characteristic folding. Interestingly, GRP does not bind beta-galactosides. In order to study in detail the entirety of the galectin family for themes of divergence and recognition within a limited number of proteins, G. gallus GRP was chosen as model. This protein's structural resolution showed the particular hallmarks that hinder beta-galactoside binding.
Book Details: |
|
ISBN-13: |
978-613-9-82540-0 |
ISBN-10: |
6139825407 |
EAN: |
9786139825400 |
Book language: |
English |
By (author) : |
Andrea Flores-Ibarra |
Number of pages: |
112 |
Published on: |
2018-07-19 |
Category: |
Biochemistry, biophysics |