LAP Lambert Academic Publishing ( 13.12.2018 )
€ 54,90
The aim of the present study was development and optimization of an efficacious, pharmaco-economical, palatable and marketable film coated tablet formulation of Norfloxacin-Tinidazole. Bitter taste of both drugs reduces the patient compliance & hence marketability. However it has been shown that film coating technology economical & useful in masking the taste. The core tablets with maximum hardness & minimum disintegration time were selected for film coating. (F-1 & F-07) The optimized formulation F-07 showed hardness, friability, disintegration time and drug release in range 9 kg/cm2, 0.17±0.02%, 27.40±2.1 sec. & 100% release in 30 min. respectively. For all tablet formulation drug release at the end of 30 min was found in the range of 52.78±0.09 to 100.07±0.5 % and from the obtained results, F-07 was selected as an optimized formulation for designing palatable tablet. Therefore it can be concluded that the present work discusses in depth the development and optimization of an efficacious, pharmaco-economical, palatable and marketable tablet formulation of Norfloxacin and Tinidazole.
Детали книги: |
|
ISBN-13: |
978-613-9-97736-9 |
ISBN-10: |
6139977363 |
EAN: |
9786139977369 |
Язык книги: |
English |
By (author) : |
Anilkumar Shinde |
Количество страниц: |
96 |
Опубликовано: |
13.12.2018 |
Категория: |
Фармацевтика |