LAP Lambert Academic Publishing ( 27.02.2017 )
€ 49,90
The objective of this study is to formulate and evaluate the sustained release matrix tablet of Tizanidine Hydrochloride by direct compression method. In the present study, Tizanidine is chosen as a model drug which is Muscle relaxant. Because of its short half life (2.5hrs), its water solubility and less bioavailability (40%) it was chosen as a suitable candidate for sustain matrix tablet formulation. It was formulated in to matrix tablet using polymer such as iota-Carrageenan and Polyethylene oxide as releases retardants. All the pre-compression parameters, post-compression parameters were found to be within the standard IP limits. Matrix tablet with Carrageenan and Polyethylene oxide successfully sustained the release of Tizanidine for a period of 12hrs. The concentration of tizanidine was kept constant, MCC-101 and lactose (1:3 ratio) used as filler. The maximum in-vitro release (at 50rpm, temperature 37±0.5°C, and 0.1N HCl, pH 6.8 phosphate buffers) was found to be 97.8% and 98.6% over a period of 12hrs for formulations C4 and P4. The data of in-vitro release from tablets were fitted to different kinetic models to explain the release profile. Formulations C4 and P4 were best
Детали книги: |
|
ISBN-13: |
978-3-330-05156-0 |
ISBN-10: |
3330051566 |
EAN: |
9783330051560 |
Язык книги: |
English |
Edited by: |
Yamsani Vamshi Vishnu |
Количество страниц: |
104 |
Опубликовано: |
27.02.2017 |
Категория: |
Фармацевтика |