Formulation and Evaluation of Pulsatile Release Tablet of Lornoxicam

The aim of present research work is to develop single pulse pulsatile release tablets that release Lornoxicam instantly after the lag time of about 5 hour which can be used for treatment of rheumatoid arthritis where symptoms are at their prime in the morning hours. Such a pulsatile release tablet of Lornoxicam taken at bed time and release the drug in early morning, thus enhance patient compliance. From various approaches erodible compression coating system is selected for the formulation of pulsatile release tablets, in which outer coating containing mixture of hydrophilic polymer (sodium alginate) and hydrophobic polymer (ethylcellulose). The release profile of compression coated tablet exhibited lag time followed by burst release, in which outer shell break into two halves.