LAP Lambert Academic Publishing ( 2012-07-31 )
€ 49,00
The purpose of this research was to prepare and characterize Aceclofenac microsphere of guar gum polymer for the application of inflammation. Method: - The microsphere were prepared by using emulsification method using starch cross-linked agent and coating was done by solvent evaporation method with the pH sensitive eudragit S-100 polymers. Result:-The prepared microsphere were white, free flowing and spherical in shape. The drug-loaded microsphere showed entrapment efficiency and drug release was extended upto 6 to 8 h. The infrared spectra, differential scanning calorimetry thermographs spectra all showed the stable character of both the drugs in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. The stability study was conducted to conform the stability of prepared microsphere. In-vitro drug release study was performed in both simulated gastrointestinal fluid medium and rat cecal content of different pH. Conclusion:-The prepared Aceclofenac microsphere has the potential for delaying the release of drug.
Book Details: |
|
ISBN-13: |
978-3-659-20232-2 |
ISBN-10: |
3659202320 |
EAN: |
9783659202322 |
Book language: |
English |
By (author) : |
Sofiya Verma |
Number of pages: |
96 |
Published on: |
2012-07-31 |
Category: |
Pharmacy |