Estimation of clotrimazole and beclomethasone dipropionate

Analytical method development for estimation of Clotrimazole(CT) and Beclomethasone dipropionate(BD) in pharmaceutical formulation. The combination of CT and BD is use as antifungal and anti-inflammatory. This combination is available as topical cream and lotion form. CT and BD both are official in IP, BP and USP but their combination is not official in any pharmacopoeia; hence no official method is available for the estimation of these two drugs in combined dosage forms. The objective of work is to develop and validate Spectrophotometric methods,RP-HPLC and HPTLC for simultaneous estimation of clotrimazole and beclomethasone dipropionate in pharmaceutical dosage form (lotion, cream).