Effect of SA and ASA on the growth of HT3 and HeLa cervical cancer

Cervical cancer is among the cancers affecting women worldwide with high mortality rate. Human papillomavirus (HPV) is the most risk factor for cervical cancer infection, almost 99% of cervical cancers worldwide, apart from other factors. HPV succeeded in causing cervical cancer through up-regulation of cyclooxygenase (COX). COX is of two types, COX-1 and COX-2 and is present in small amount in every cell, and it participated in regulation in cervical cancer neoplasia. However, it is over-expressed in considerable amount in cervical cancers. Pharmacological inhibition of COX-1 and 2 decreases tumour formation, and makes it a very important tool for therapeutic and chemoprevention of cervical cancer. Non-steroidal anti-inflammatory drugs that is Acetylsalicylic acid and Salicylic acid are found to be inhibitor of cyclooxygenase enzymes, these drugs has been in application for anti-oxidative, anti-microbial as well as anti-inflammatory and could be applied as anti-tumour drugs in many cancer cell lines, there is also possibility that Acetylsalicylic acid and Salicylic acid inhibits angiogenesis by inhibition of COX in cervical cancer.