SELF-ASSEMBLY AND CHEMO-LIGATION OF POLYMERIC RESPONSIVE MICROGELS

SELF-ASSEMBLY AND CHEMO-LIGATION OF POLYMERIC RESPONSIVE MICROGELS

Phase Behavior and Click Chemistry of Multi-Responsive Polymeric Microgel Dispersions

LAP Lambert Academic Publishing ( 20.07.2010 )

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Microgels are sub-micron to micron-size polymeric networks confined in limited space swollen by a good solvent, also called hydrogel microparticles or microspheres if swollen in water. Among all microgels investigated nowadays, poly(N-isopropylacrylamide), pNIPAm, microgels are one of the most extensively studied microgel particles due to their volume phase transition (VPT) at lower critical solution temperature (LCST). By incorporation of pH-responsive monomer, acrylic acid (AAc), copolymeric pNIPAm-AAc microgels further demonstrate multi-responsivity to temperature, pH, and ionic strength. A temperature-programmed polymerization protocol is proposed for the synthesis of large pNIPAm-AAc microgel particles with a hydrodynamic diameter of 2~5 μm. Futhermore, to observe the phase behavior of pNIPAm-AAc microgel dispersions, pNIPAm-AAc dispersions at various pH values and concentrations were allowed to age and undergo phase transition in closed system. Finally, the Cu(I)-catalyzed azide-terminal alkyne 1,3-dipolar cycloaddition, also called Sharpless-Meldal “click” reaction, is used to functionalize pNIPAm-AAc microgel particles for microgel bioconjugation and medical applications.

Kitap detayları:

ISBN-13:

978-3-8383-8710-9

ISBN-10:

3838387104

EAN:

9783838387109

Kitabın dili:

English

Yazar:

Zhiyong Meng

Sayfa sayısı:

172

Yayın tarihi:

20.07.2010

Kategori:

Fiziksel kimya