LAP Lambert Academic Publishing ( 16.09.2010 )
€ 49,00
In this book we highlight the strong synthetic potential and scope of transition metal-catalyzed rearrangement reactions for fully economical and complex carbon-carbon bond forming reactions. The Meyer-Schuster and the Rupe rearrangements are emerging as the methods of choice for the homologation of carbonyl compounds into α,β-unsaturated aldehydes and ketones, particularly useful for the synthesis of many hindered ketones. The Rautenstrauch-I and Rautenstrauch-II rearrangements of readily propargylic derivatives are very useful reactions for the synthesis of complex cyclopentenones, and bicyclo[n.1.0] enol carboxylates in high chemical yields, which proceed under mild reaction conditions with high stereoselectivity, and total transfer of chirality. In the case of Rautenstrauch-II, the basic-methanolysis of the resulting compounds provides bicyclo[n.1.0]ketones, valuable building blocks for the preparation of natural products. A reaction mechanism has been advanced, and confirmed by experimental evidences, which supports the involvement of metallo-carbenes as key species formed through a cyclopropanation event that precedes the 1,2-acyloxy migration.
Kitap detayları: |
|
ISBN-13: |
978-3-8433-5328-1 |
ISBN-10: |
384335328X |
EAN: |
9783843353281 |
Kitabın dili: |
English |
Yazar: |
JOSÉ MARCO-CONTELLES |
Sayfa sayısı: |
60 |
Yayın tarihi: |
16.09.2010 |
Kategori: |
Organik kimya |