LAP Lambert Academic Publishing ( 2018-08-25 )
€ 76,90
Antibiotics are one of our most important weapons to cover bacterial infections and improve human life . Infectious diseases are the leaders among the challenging drug targets because of the multi-drug resist antimicrobial pathogens and continuous rise in the emerging infections from known and unknown sources. Tyrosine kinases are orally active, small molecules that have a favorable safety profile and can be easily combined with other forms of chemotherapy or radiation therapy. The combination of two pharmacophores into a single molecule is an effective and commonly used direction in modern medicinal chemistry for the exploration of novel and highly active compounds. A variety of safe and effective antiinflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. The pharmacophoric structural features of the selective COX-2 inhibitors possess a central heterocyclic five member ring system bearing two vicinal aryl moieties, such as pyrazole (celecoxib), 2(5H) furanone (rofecoxib), and isoxazole (valdecoxib).
Book Details: |
|
ISBN-13: |
978-613-9-89648-6 |
ISBN-10: |
6139896487 |
EAN: |
9786139896486 |
Book language: |
English |
By (author) : |
Dhananjay Mane |
Number of pages: |
220 |
Published on: |
2018-08-25 |
Category: |
Organic chemistry |